mitochondrial diseases การใช้

• Occasionally CPEO may be caused by conditions other than mitochondrial diseases.
• The technique represents a way to prevent the inheritance of mitochondrial diseases.
• Some medical conditions are carried only by the female line such as Mitochondrial diseases.
• Complex I deficiency is the reason behind over thirty percent of human mitochondrial diseases.
• A mutation in the genes regulating any of these functions can result in mitochondrial diseases.
• Mutations in nuclear genes that encode proteins that mitochondria use can also contribute to mitochondrial diseases.
• The family trees involving mitochondrial diseases baffled them until they learned that fathers do not pass on mitochondrial genes.
• Women with a family history of mitochondrial diseases will be able to have children without risk of passing on these diseases.
• Mitochondrial diseases are sometimes ( about 15 % of the time ) caused by mutations in the mitochondrial DNA that affect mitochondrial function.
• Mitochondrial diseases take on unique characteristics both because of the way the diseases are often inherited and because mitochondria are so critical to cell function.
• Defective cytochrome c oxidase activity was found in mitochondrial diseases and in human Stress-dependent reversible dephosphorylation of cytochrome c oxidase suggests formation of reactive oxygen species.
• Unlike typical mitochondrial diseases caused by mitochondrial DNA ( mtDNA ) mutations, MNGIE is caused by mutations in the TYMP gene, which encodes the enzyme thymidine phosphorylase.
• In 2004, the Newcastle University applied for a licence to develop pronuclear transfer to avoid the transmission of mitochondrial diseases, and was granted the license in 2005.
• His most recent studies have focused on mitochondrial DNA stability and maintenance in Caenorhabditis elegans through the study of the various genes involved, especially of the candidate genes for mitochondrial diseases.
• Mutations in the " POLG " gene are associated with several mitochondrial diseases, including Alpers'disease, ataxia-neuropathy disorders, and dominant and recessive forms of progressive external ophthalmoplegia.
• As a rule, mitochondrial diseases are worse when the defective mitochondria are present in the muscles, cerebrum, or nerves, because these cells use more energy than most other cells in the body.
• Although mitochondrial diseases vary greatly in presentation from person to person, several major clinical categories of these conditions have been defined, based on the most common phenotypic features, symptoms, and signs associated with the particular mutations that tend to cause them.
• Research in this area also covers rare genetic diseases, particularly glycogenosis type II, storage diseases ( Gaucher, Niemann Pick and other sphyngolipidoses ) mitochondrial diseases and genetic immunodeficiencies such as IPEX syndrome, aiming at clarifying molecular mechanisms and develop innovative approaches to treatment such as enzyme replacement, use of nanotechnologies for genetic correction and stem cells transplantation.
• Rather, this is a case where the court deemed it plausible that vaccines aggravated an underlying disease caused by bad mitochondria, and that some of the symptoms Hannah showed were similar to autism, " and Julie Gerberding said, " Let me be very clear that the government has made absolutely no statement indicating that vaccines are a cause of autism . " It has also been noted that Hannah's mitochondrial disease is very rare, and that no evidence proves that it is possible for vaccines to cause or worsen mitochondrial diseases, with Chuck Mohan of the United Mitochondrial Disease Foundation noting that " there is very little scientific research in this area . " In addition, Paul Offit has argued that the VICP's concession to Hannah was " poorly reasoned " and contended that this program had " turned its back on science " in recent years.